An overview of both recent and fundamental developments of instrumentation that are revolutionizing the field of analytical chemistry, with an emphasis on applications in biological chemistry and biotechnology. Topics will include a survey of advanced analytical techniques, including specialized mass spectrometry techniques, x-ray photoelectron spectroscopy, Auger electron spectroscopy, Electron Microscopy, Surface Enhanced Raman spectroscopy, Localized surface plasmon resonance, total internal reflection fluorescence methods; chemometrics, and other state-of-the-art analytical methods. Course work will include independent review of peer-reviewed literature, scientific writing, and student oral presentations