Genetic information shapes almost all aspects of life. How is this information organized and inherited? How does it influence individuals and how does help to understand disease? The course explores the structure and function of chromatin i.e. the management of biological information. We will explore how the genome is packaged, expressed, replicated and repaired. We will look into chromosome sets and inheritance, accessibility of the genome to the molecular machinery, DNA repair, and modern techniques in research and diagnostics.