An overview of both recent and fundamental developments of instrumentation that are revolutionizing the field of analytical chemistry, with an emphasis on applications in biological chemistry and biotechnology. Topics will include specialized mass spectrometry techniques, including secondary ion, fast atom bombardment and ion cyclotron resonance mass spectrometry methods; GC/MS and LC/MS interfaces; a survey of surface-oriented techniques including x-ray photoelectron spectroscopy, Auger electron spectroscopy, Raman spectroscopy, attenuated total reflection methods, total internal reflection fluorescence methods; Fourier transform theory and methods; microcomputer interfacing and chemometrics. Course work will include independent literature reviews and student presentations.