The chemistry of benzene, alcohols, aldehydes, ketones, carboxylic acid, esters, acid chlorides, amides and amines will be covered. As well, electrophilic aromatic substitution, protection and deprotection of alcohols, nucleophilic acyl substitution, nucleophilic addition, carbonyl alpha-substitution reaction, keto-enol tautomerism, carbonyl condensation and amines will be introduced. The emphasis will be on organic mechanisms and application of organic reactions to multistep synthesis. Continues from CHM242H5.

This courses provides a richly rewarding opportunity for students in their second year to work in the research project of a professor in return for 299Y course credit. Students enrolled have an opportunity to become involved in original research, learn research methods and share in the excitement and discovery of acquiring new knowledge. This course does not count as one of the requirements in the Chemistry Minor, Chemistry Major, Chemistry Specialist or Biological Chemistry Specialist programs. Participating faculty members post their project descriptions for the following summer and fall/winter sessions in early February and students are invited to apply in early March. See Experiential and International Opportunities for more details.

Introduction to the basic theory and practice underlying important techniques in analytical chemistry, chosen from three major areas of instrumental analysis: spectroscopy, electrochemistry and separation science. Specific topics will include fluorescence spectroscopy, atomic spectroscopy, x-ray fluorescence, voltammetry, high resolution gas and liquid chromatography, mass spectrometry, and a brief introduction to computer applications, including Fourier transform methods. A problem-based approach will be used to explore these methods in a wide variety of practical applications, which will include individualized student assignments.

This course covers the foundations of computational chemistry with a focus on practical applications and does not require a background in programming or quantum mechanics. An array of methods for predicting the structural, electronic, thermodynamic, and spectroscopic properties of chemical species will be addressed, as well as how the calculated results can complement experimental observations. Relevant fundamental theories to computational chemistry will be covered on a need-to-know basis. Students will follow an individualized study path and select the chemical systems to which each method will be applied.

Chemistry of metallic elements. Organometallics. Main group and transition elements. Rings, cages and clusters. Lanthanides and Actinides. Applications of IR, UV-VIS and multinuclear NMR spectroscopy. Symmetry. Inorganic synthesis. Non-aqueous solvents. Structure and bonding. Catalysis and industrial processes.

Principles of inorganic chemical reactions and their application to biochemical systems: kinetics, mechanisms and thermodynamics of ligand exchange, acid-base and redox reactions involving metalloproteins and their model compounds; mechanisms of catalysis by metalloenzymes and their model compounds; metal ion related diseases; metals in chemotherapy.

Stereochemistry and conformational analysis; mechanisms of important types of organic reaction; pericyclic reactions; reactive intermediates.

Methods used for forming carbon-carbon bonds will be reviewed, including reactions of the various types of nucleophilic carbon and the use of organometallic reagents. Other topics include functional group interconversions, oxidation and reduction and the role of elements such as boron, silicon and tin in organic synthesis.

The chemistry of selected classes of naturally occurring molecules such as those below, with emphasis on structure, stereochemistry, properties and synthesis. Amino acids, peptides, proteins, carbohydrates, lipids, nucleosides, nucleotides, and nucleic acids.

An introduction to the molecular anatomy and properties of the major cellular biomolecules: proteins, nucleic acids, carbohydrates and lipids. The course also covers the structural organization of membranes and other macromolecular complexes. Enzyme mechanisms and membrane transport phenomena will be examined in the context of quantitative analyses these processes and of structure/function relationships.

Basic principles of biological energetics. Metabolic pathways for carbohydrate and lipid synthesis and degradation. Survey of amino acid and nucleotide metabolism. Integration and cellular regulation of metabolism. Intracellular signal transduction mechanisms.

The first in a sequence of two laboratory courses intended to complement CHM361H5 and CHM362H5. Experiments are designed to familiarize students with techniques commonly used to study the chemical and physical properties of biological molecules. Topics covered in the first half also include a wide range of chromatographic and/or fractionation methods to separate proteins and/or subcellular organelles, enzyme kinetics, electrophoresis to study proteins and their complexes. The theoretical basis for each experiment will be covered in a 1-hour lecture each week.

The second in a sequence of two laboratory courses intended to complement CHM361H5 and CHM362H5. CHM373H5 carries on from CHM372H5 with a particular emphasis on protein purification, enzyme kinetics and protein characterization (e.g., kinetics, reactions, binding, depending on the protein studied). Techniques covered include classic biochemical techniques used in studying proteins and protein complexes, such as chromatography and fluorescence methods. The theoretical basis for each experiment will be covered in a 1-hour lecture each week.

The first in a sequence of two laboratory courses in synthetic chemistry. This laboratory course comprises the synthesis of inorganic and organic compounds supplemented by physical measurements (e.g., ir, uv, 1H NMR spectra, magnetic susceptibility, etc.) of the products where appropriate. Approximately six weeks each will be spent on two groups of foundational experiments, one in organic and one in inorganic synthesis to illustrate techniques of chemical synthesis. The central role of the carbonyl group in organic synthesis is elaborated, an organic unknown is identified both chemically and spectroscopically and the synthetic chemistry of the first row transition elements is explored.

The second in a sequence of two laboratory courses in synthetic chemistry that builds on the foundations established in CHM394H5. Students choose their own experiments in this course from offerings comprising the synthesis of organic, organometallic and inorganic compounds and in computational chemistry. Techniques such as working at low temperatures and in inert atmospheres (e.g., glove box) are introduced. Depending on the experiments actually chosen, a mixed organic unknown is separated and identified, organic rearrangements and the synthetic chemistry of elements from across the Periodic Table including main group, transition elements and lanthanides are explored. A highlight is an optional four week independent synthesis project in any area of synthetic chemistry adapting procedures from the published, including recent, research literature.

This analytical and physical chemistry laboratory course represents an integration of the study of fundamental physical chemistry with wide-ranging applications to instrumental methods of analysis, such as separation science, electrochemistry and spectroscopy. The course will provide a solid hands-on grounding in many of the major topics covered in analytical and physical chemistry, and the optimization of instrumental analytical measurements by the application of physical principles. Students select from a variety of instruments to customize their program, and develop their own analytical methods to address analytical problems of interest to the student.

This analytical and physical chemistry laboratory course carries on from CHM396 to introduce more advanced topics in instrumental methods of analysis and physical chemistry concepts. The course will include experimental modules focused on instrument design and computer interfacing, molecular spectroscopy (e.g. fluorescence, infrared and Raman, and NMR), plasmon resonance methods for biomolecule determinations and kinetic analysis, microfluidics and lab-on-a-chip technologies. The course will provide practical experience in the optimization of instrumental analytical measurements, experiment design, and topics of relevance to research in analytical and physical chemistry.

This course provides third-year undergraduate students (after completion of 8.0 credits) who have developed some knowledge of Chemistry and its research methods, an opportunity to work in the research project of a professor in return for course credit. Students enrolled have the opportunity to become involved in original research, enhance their research skills and share in the excitement of acquiring new knowledge and in the discovery process of science. This course does not count as one of the requirements in the Chemistry Minor program. Participating faculty members post their project descriptions for the following summer and fall/winter sessions in early February and students are invited to apply in early March. See Experiential and International Opportunities for more details.

An exploration of biomolecule analysis methodologies, with an emphasis on nucleic acid analysis, will be done from the perspective of the Analytical Biochemist. The course will begin with brief reviews of the structure and function of biomolecules, solid-phase synthesis, extraction, pre-concentration and amplification methods. This will be followed by an exploration of established and emerging techniques for target biomolecule determinations, including: bioprobes, microarrays, biosensors and DNA sequencing technologies (including single molecule approaches). Current examples of implementation in the fields of proteomics and genomics will be discussed throughout the course, with an emphasis on life sciences and diagnostic testing applications. Course work will include independent literature reviews and student presentations.

An overview of both recent and fundamental developments of instrumentation that are revolutionizing the field of analytical chemistry, with an emphasis on applications in biological chemistry and biotechnology. Topics will include a survey of advanced analytical techniques, including specialized mass spectrometry techniques, x-ray photoelectron spectroscopy, Auger electron spectroscopy, Electron Microscopy, Surface Enhanced Raman spectroscopy, Localized surface plasmon resonance, total internal reflection fluorescence methods; chemometrics, and other state-of-the-art analytical methods. Course work will include independent review of peer-reviewed literature, scientific writing, and student oral presentations

Separation science will be explored by building on a survey of fundamental physical principles to understand processes of extraction, and technologies such as solid phase microextraction, supercritical fluid extraction, immunoaffinity extraction and molecularly imprinted polymers. Plate and rate theory will be developed to consider various forms of gas and liquid chromatographic methods, including hyphenated techniques that bridge to information detectors such as mass spectrometers. New opportunities for chromatography and separations by movement to small scale size will be considered by focusing on microfluidics, electro-osmotic flow and chip based microdevice applications. Applications examples will focus on problems in life sciences, forensics and environmental chemistry. Course work will include independent literature reviews and student presentations.

Modern metal-mediated (inorganic) reactions useful in organic synthesis. Applications of advanced organometallic chemistry. Selected solid-state compounds: metal-organic frameworks, nanoparticles and related materials for separation, catalysis, diagnostics.

Applications of advanced fundamentals to, and recent developments in, multi-step organic synthesis.

An introduction to drug discovery, design and development. This course will focus on the potential of proteins (enzymes, receptors, receptor structure and signal transduction) as targets for molecular therapeutic intervention. The strategies of finding a drug target, optimizing target interactions and synthetic molecular therapeutic development will all be considered and discussed. The modern technologies of targeting protein-protein interactions will also be covered.

Discussion course based on published research in biological chemistry and applications of chemistry to study processes of biological significance.

A dissertation will be written based on literature research of a topic of current interest in the field of chemistry. The research will be conducted under the supervision of a chemistry faculty member other than the student's CPS489Y5 supervisor. The research topic must not overlap that of the student's CPS489Y5 project. The goals of this course are to achieve literature research expertise as well as in-depth knowledge of a particular chemistry topic, while perfecting scientific writing and oral presentation skills. Evaluation is based on a final written report describing the aims and results of the research, as well as an oral presentation of the work. The course is normally taken in the student's fourth year, in either the Fall or Winter terms, but may be taken in the Summer term. Enrolment in CHM485H5 requires submitting an application to the department before the end of the term prior to that in which it is intended to undertake the research. Independent Studies Application Forms may be found at http://uoft.me/cpsforms. Applications should be submitted to the CPS Undergraduate Assistant. Registration on ACORN is also required. Students are encouraged to consult with, and obtain the consent of, prospective supervisors before applying for enrolment. 

An experimental or theoretical research topic in chemistry will be investigated under the supervision of a chemistry faculty member other than the student's CHM485H5 supervisor. The research topic must not overlap that of the student's CHM485H5 research topic. In addition to learning to plan, conduct and evaluate a research program, students will receive training in written and oral presentation skills. Evaluation is based on interim and final written reports describing the aims and results of the research, as well as interim and final oral presentations of the work. The course is normally taken in the student's fourth year. Enrolment in CHM489Y5 requires submitting an application to the department in the spring term, with the application due date being the final day of classes. Independent Studies Application Forms may be found at http://uoft.me/cpsforms. Applications should be submitted to the CPS Undergraduate Assistant. Registration on ACORN is also required. Acceptance into the course is dependent on the student having achieved a satisfactory GPA, and reaching agreement with a potential supervisor. Students must consult with prospective supervisors before applying for enrolment, and must list at least two faculty members as possible supervisors. This course is restricted to students in the Chemistry Major, Biological Chemistry Specialist, and Chemistry Specialist Programs.

Introduction to film analysis, concepts of film style and narrative. Topics include documentary, avant-garde, genres, authorship, ideology, and representation.

Looking at a few periods of intense technological change—for example, with the invention of photography, and the introduction of sound, of colour, of television—we will consider the ways in which artists, filmmakers, studios, and media conglomerates have responded to such changes and to accompanying ideas about the role that moving technology plays in our conception of history and the future.

The establishment of film as a serious art form is coincident with the earliest critical writing on Alfred Hitchcock that emerged in the 1950s. Since then, Hitchcock has remained one of the most important filmmakers of all time, spawning not only a massive body of critical scholarship but also legions of imitators. This course will serve as an introduction to both the films (such as Psycho and North by Northwest) and related issues: questions of suspense, authorship, morality, and spectatorship.